How is Depression Related to Mild Cognitive Impairment in Older Adults?

An article published in a recent issue of GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry reviews the relationship between depressive symptoms and mild cognitive impairment (MCI) in older adults. Evidence bearing on this relation comes from clinical findings, neuroimaging, and cerebrospinal fluid markers. Depression in elderly people is associated with a higher occurrence of cognitive impairment, whereas the decline of cognitive functions over time seems to be a predictor of the development of dementia. Further symptoms predicting a high risk of progression from MCI to dementia are: anxiety, restlessness, and low awareness of cognitive malfunction. There are controversies in the literature, however, about the connections among vascular brain lesions, depression, and MCI. Frontal and temporal brain regions seem to be at the core of functional changes in MCI patients. Several studies of cerebrospinal fluid point out the role of tau protein in predicting the outcome of MCI over time. In conclusion, diagnosis of MCI demands a complex assessment. MCI patients with and without depression need careful follow-up investigations.

For the abstract.